Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment

Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment

Abstract Background Cardiac differentiation from human pluripotent stem cells provides a unique opportunity to study human heart development in vitro and offers a potential cell source for cardiac regeneration. Compared to the large body of studies investigating cardiac maturation and cardiomyocyte...

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Main Authors: Hang Ruan, Yingnan Liao, Zongna Ren, Lin Mao, Fang Yao, Peng Yu, Youqiong Ye, Zhao Zhang, Shengli Li, Hanshi Xu, Jiewei Liu, Lixia Diao, Bingying Zhou, Leng Han, Li Wang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Biology
Subjects:
Cardiac lineage commitment
Human pluripotent stem cells
Single-cell RNA sequencing
Cell-cell crosstalk
ETS1
Transcription regulation
Online Access:http://link.springer.com/article/10.1186/s12915-019-0709-6

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