Effects of Ginaton combined with batroxobin on oxidative stress, hemodynamics and coagulation in SHL patients

• Main Authors: Yan Zhao, Shi-Jia Lai, Ru-Tao Ai, Jian-Ming Huang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-11-01
• Series: Journal of Hainan Medical University
• Subjects: Ginaton; Batroxobin; Sudden hearing loss; Oxidative stress; Hemodynamics; Coagulation
• Online Access: http://www.hnykdxxb.com/PDF/201721/35.pdf

Objective: To investigate the effects of ginaton combined with batroxobin on oxidative stress, hemodynamics and coagulation in patients with sudden hearing loss. Methods: According to random data table method, 100 cases of sudden hearing loss were randomly divided into the control group (n=50) and observation group (n=50), patients in the control group were given batroxobin treatment, the observation group received ginaton combined with batroxobin theraphy.The levels of oxidative stress, hemodynamics and coagulation were compared between the two groups before and after treatment. Results: The levels of WBV, HCT, PV, APTT, PT, TT, PF, SOD, LPO in the two groups before treatment were not statistically significant. After treatment, the levels of WBV, PV in the control group and observation group were respectively (5.33±0.62) mPa•s, (1.73±0.59) mPa•s and (4.07±0.55) mPa•s, (1.32±0.41) mPa•s, which were significantly lower than those before treatment, and after treatment in the observation group the levels of WBV, PV were significantly lower than the control group; After treatment, the levels of APTT, PT, TT, PF in the control group and observation group were respectively (43.75±6.15) s, (18.23±2.02) s, (15.38±2.51) s, (58.61±12.96) µg/L and (53.68±7.16) s, (24.67±4.35) s, (22.51±4.85) s, (41.47±8.63) µg/L, compared with those in the same group before treatment, the levels of APTT, PT and TT were significantly increased, PF level was significantly decreased, and in the observation group APTT, PT and TT levels were significantly higher and PF level was significantly lower than that in the control group. After treatment, the levels of SOD, LPO in the control group and observation group were respectively (101.78±10.53) nu/L, (5.91±0.95) mmol/L and (110.07±12.62) nu/L, (4.68±1.02) mmol/L compared with those in the same group before treatment, the level of SOD were significantly increased, the level of LPO level was significantly decreased, and in the observation group LPO level was significantly lower and SOD level was significantly higher than that in the control group. Conclusion Compared with the use of batroxobin alone, Ginaton combined with batroxobin can better reduce the stress response, improve hemodynamics and coagulation in patients with sudden hearing loss.