Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

Hypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.

Bibliographic Details
Main Authors:	Md Habibur Rahman, Anup Bhusal, Jae-Hong Kim, Mithilesh Kumar Jha, Gyun Jee Song, Younghoon Go, Il-Sung Jang, In-Kyu Lee, Kyoungho Suk
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19576-1

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spelling	doaj-ab0aa5b82f814602985d6ffd3a2191a42021-05-11T08:05:42ZengNature Publishing GroupNature Communications2041-17232020-11-0111112010.1038/s41467-020-19576-1Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetesMd Habibur Rahman0Anup Bhusal1Jae-Hong Kim2Mithilesh Kumar Jha3Gyun Jee Song4Younghoon Go5Il-Sung Jang6In-Kyu Lee7Kyoungho Suk8BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National UniversityBK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National UniversityBK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National UniversityDepartment of Neurology, Johns Hopkins UniversityDepartment of Medical Science, College of Medicine, Catholic Kwandong UniversityKorean Medicine Application Center, Korea Institute of Oriental MedicineDepartment of Pharmacology, School of Dentistry, Kyungpook National UniversityDepartment of Internal Medicine, School of Medicine, Kyungpook National University HospitalBK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National UniversityHypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.https://doi.org/10.1038/s41467-020-19576-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Md Habibur Rahman Anup Bhusal Jae-Hong Kim Mithilesh Kumar Jha Gyun Jee Song Younghoon Go Il-Sung Jang In-Kyu Lee Kyoungho Suk
spellingShingle	Md Habibur Rahman Anup Bhusal Jae-Hong Kim Mithilesh Kumar Jha Gyun Jee Song Younghoon Go Il-Sung Jang In-Kyu Lee Kyoungho Suk Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes Nature Communications
author_facet	Md Habibur Rahman Anup Bhusal Jae-Hong Kim Mithilesh Kumar Jha Gyun Jee Song Younghoon Go Il-Sung Jang In-Kyu Lee Kyoungho Suk
author_sort	Md Habibur Rahman
title	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_short	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_full	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_fullStr	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_full_unstemmed	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_sort	astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-11-01
description	Hypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.
url	https://doi.org/10.1038/s41467-020-19576-1
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Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

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