A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.

Bibliographic Details
Main Authors: Guodong Li, Chung-Nga Ko, Dan Li, Chao Yang, Wanhe Wang, Guan-Jun Yang, Carmelo Di Primo, Vincent Kam Wai Wong, Yaozu Xiang, Ligen Lin, Dik-Lung Ma, Chung-Hang Leung
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23448-7
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spelling doaj-ab01c58730bb45109483db19c65692d42021-06-13T11:14:54ZengNature Publishing GroupNature Communications2041-17232021-06-0112111110.1038/s41467-021-23448-7A small molecule HIF-1α stabilizer that accelerates diabetic wound healingGuodong Li0Chung-Nga Ko1Dan Li2Chao Yang3Wanhe Wang4Guan-Jun Yang5Carmelo Di Primo6Vincent Kam Wai Wong7Yaozu Xiang8Ligen Lin9Dik-Lung Ma10Chung-Hang Leung11State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauDepartment of Chemistry, Hong Kong Baptist UniversityState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauDepartment of Chemistry, Hong Kong Baptist UniversityState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauLaboratoire ARNA, University of BordeauxState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and TechnologyShanghai East Hospital of Tongji University, School of Life Sciences and Technology, Tongji UniversityState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauDepartment of Chemistry, Hong Kong Baptist UniversityState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauImpaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.https://doi.org/10.1038/s41467-021-23448-7
collection DOAJ
language English
format Article
sources DOAJ
author Guodong Li
Chung-Nga Ko
Dan Li
Chao Yang
Wanhe Wang
Guan-Jun Yang
Carmelo Di Primo
Vincent Kam Wai Wong
Yaozu Xiang
Ligen Lin
Dik-Lung Ma
Chung-Hang Leung
spellingShingle Guodong Li
Chung-Nga Ko
Dan Li
Chao Yang
Wanhe Wang
Guan-Jun Yang
Carmelo Di Primo
Vincent Kam Wai Wong
Yaozu Xiang
Ligen Lin
Dik-Lung Ma
Chung-Hang Leung
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
Nature Communications
author_facet Guodong Li
Chung-Nga Ko
Dan Li
Chao Yang
Wanhe Wang
Guan-Jun Yang
Carmelo Di Primo
Vincent Kam Wai Wong
Yaozu Xiang
Ligen Lin
Dik-Lung Ma
Chung-Hang Leung
author_sort Guodong Li
title A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
title_short A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
title_full A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
title_fullStr A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
title_full_unstemmed A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
title_sort small molecule hif-1α stabilizer that accelerates diabetic wound healing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.
url https://doi.org/10.1038/s41467-021-23448-7
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