A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.
Bibliographic Details
| Main Authors: |
Guodong Li,
Chung-Nga Ko,
Dan Li,
Chao Yang,
Wanhe Wang,
Guan-Jun Yang,
Carmelo Di Primo,
Vincent Kam Wai Wong,
Yaozu Xiang,
Ligen Lin,
Dik-Lung Ma,
Chung-Hang Leung |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23448-7
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