Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or tran...

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Main Authors:	Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald, Bruce R. Blazar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-01-01
Series:	Frontiers in Immunology
Subjects:	regulatory T cell tTreg iTreg microRNA graft-versus-host disease
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00057/full

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spelling	doaj-aaffc48bb9644c21a7c85844da35dd9a2020-11-24T22:57:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-01-01910.3389/fimmu.2018.00057326381Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host DiseaseKeli L. Hippen0Michael Loschi1Jemma Nicholls2Kelli P. A. MacDonald3Bruce R. Blazar4Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesThe Antigen Presentation and Immunoregulation Laboratory and Bone Marrow Transplantation Laboratory, QIMR Berghofer Medical Research Institute, University of Minnesota Cancer Center, Brisbane, QLD, AustraliaDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesRegulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00057/fullregulatory T celltTregiTregmicroRNAgraft-versus-host disease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Keli L. Hippen Michael Loschi Jemma Nicholls Kelli P. A. MacDonald Bruce R. Blazar
spellingShingle	Keli L. Hippen Michael Loschi Jemma Nicholls Kelli P. A. MacDonald Bruce R. Blazar Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease Frontiers in Immunology regulatory T cell tTreg iTreg microRNA graft-versus-host disease
author_facet	Keli L. Hippen Michael Loschi Jemma Nicholls Kelli P. A. MacDonald Bruce R. Blazar
author_sort	Keli L. Hippen
title	Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_short	Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_full	Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_fullStr	Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_full_unstemmed	Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_sort	effects of microrna on regulatory t cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2018-01-01
description	Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.
topic	regulatory T cell tTreg iTreg microRNA graft-versus-host disease
url	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00057/full
work_keys_str_mv	AT kelilhippen effectsofmicrornaonregulatorytcellsandimplicationsforadoptivecellulartherapytoameliorategraftversushostdisease AT michaelloschi effectsofmicrornaonregulatorytcellsandimplicationsforadoptivecellulartherapytoameliorategraftversushostdisease AT jemmanicholls effectsofmicrornaonregulatorytcellsandimplicationsforadoptivecellulartherapytoameliorategraftversushostdisease AT kellipamacdonald effectsofmicrornaonregulatorytcellsandimplicationsforadoptivecellulartherapytoameliorategraftversushostdisease AT brucerblazar effectsofmicrornaonregulatorytcellsandimplicationsforadoptivecellulartherapytoameliorategraftversushostdisease
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Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

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