Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma
Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old...
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Online Access: | http://dx.doi.org/10.1155/2012/284064 |
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doaj-aaf639564980470ba475238818a81f572020-11-24T22:43:10ZengHindawi LimitedCase Reports in Pathology2090-67812090-679X2012-01-01201210.1155/2012/284064284064Dome-Type: A Distinctive Variant of Colonic AdenocarcinomaGiacomo Puppa0Mariella Molaro1Service de Pathologie Clinique, Hôpitaux Universitaires de Genève, 1211 Geneva, SwitzerlandDivision of Gastroenterology, “G. Fracastoro” City Hospital, Verona, ItalyIntroduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.http://dx.doi.org/10.1155/2012/284064 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giacomo Puppa Mariella Molaro |
spellingShingle |
Giacomo Puppa Mariella Molaro Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma Case Reports in Pathology |
author_facet |
Giacomo Puppa Mariella Molaro |
author_sort |
Giacomo Puppa |
title |
Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma |
title_short |
Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma |
title_full |
Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma |
title_fullStr |
Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma |
title_full_unstemmed |
Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma |
title_sort |
dome-type: a distinctive variant of colonic adenocarcinoma |
publisher |
Hindawi Limited |
series |
Case Reports in Pathology |
issn |
2090-6781 2090-679X |
publishDate |
2012-01-01 |
description |
Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management. |
url |
http://dx.doi.org/10.1155/2012/284064 |
work_keys_str_mv |
AT giacomopuppa dometypeadistinctivevariantofcolonicadenocarcinoma AT mariellamolaro dometypeadistinctivevariantofcolonicadenocarcinoma |
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1725697217826652160 |