Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma

Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old...

Full description

Bibliographic Details
Main Authors: Giacomo Puppa, Mariella Molaro
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Case Reports in Pathology
Online Access:http://dx.doi.org/10.1155/2012/284064
id doaj-aaf639564980470ba475238818a81f57
record_format Article
spelling doaj-aaf639564980470ba475238818a81f572020-11-24T22:43:10ZengHindawi LimitedCase Reports in Pathology2090-67812090-679X2012-01-01201210.1155/2012/284064284064Dome-Type: A Distinctive Variant of Colonic AdenocarcinomaGiacomo Puppa0Mariella Molaro1Service de Pathologie Clinique, Hôpitaux Universitaires de Genève, 1211 Geneva, SwitzerlandDivision of Gastroenterology, “G. Fracastoro” City Hospital, Verona, ItalyIntroduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.http://dx.doi.org/10.1155/2012/284064
collection DOAJ
language English
format Article
sources DOAJ
author Giacomo Puppa
Mariella Molaro
spellingShingle Giacomo Puppa
Mariella Molaro
Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma
Case Reports in Pathology
author_facet Giacomo Puppa
Mariella Molaro
author_sort Giacomo Puppa
title Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma
title_short Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma
title_full Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma
title_fullStr Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma
title_full_unstemmed Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma
title_sort dome-type: a distinctive variant of colonic adenocarcinoma
publisher Hindawi Limited
series Case Reports in Pathology
issn 2090-6781
2090-679X
publishDate 2012-01-01
description Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.
url http://dx.doi.org/10.1155/2012/284064
work_keys_str_mv AT giacomopuppa dometypeadistinctivevariantofcolonicadenocarcinoma
AT mariellamolaro dometypeadistinctivevariantofcolonicadenocarcinoma
_version_ 1725697217826652160