Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans

Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans

Tools to visualize and quantify transcripts at single-cell resolution have enabled the dissection of spatiotemporal patterns of gene expression in animal cells and tissues. Yet the accurate quantification of transcripts at single-cell resolution remains challenging for the much smaller microbial ce...

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Main Authors: Sergio D. Moreno-Velásquez, J. Christian Pérez
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mSphere
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00411-21
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spelling doaj-aaee277e451b4670a579e1972a807f862021-09-21T19:41:35ZengAmerican Society for MicrobiologymSphere2379-50422021-08-016410.1128/mSphere.00411-21Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicansSergio D. Moreno-Velásquez0J. Christian Pérez1https://orcid.org/0000-0001-5790-1481Interdisciplinary Center for Clinical Research, University Hospital Würzburg, Würzburg, GermanyDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA Tools to visualize and quantify transcripts at single-cell resolution have enabled the dissection of spatiotemporal patterns of gene expression in animal cells and tissues. Yet the accurate quantification of transcripts at single-cell resolution remains challenging for the much smaller microbial cells.https://journals.asm.org/doi/10.1128/mSphere.00411-21
collection DOAJ
language English
format Article
sources DOAJ
author Sergio D. Moreno-Velásquez
J. Christian Pérez
spellingShingle Sergio D. Moreno-Velásquez
J. Christian Pérez
Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans
mSphere
author_facet Sergio D. Moreno-Velásquez
J. Christian Pérez
author_sort Sergio D. Moreno-Velásquez
title Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans
title_short Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans
title_full Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans
title_fullStr Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans
title_full_unstemmed Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans
title_sort imaging and quantification of mrna molecules at single-cell resolution in the human fungal pathogen candida albicans
publisher American Society for Microbiology
series mSphere
issn 2379-5042
publishDate 2021-08-01
description Tools to visualize and quantify transcripts at single-cell resolution have enabled the dissection of spatiotemporal patterns of gene expression in animal cells and tissues. Yet the accurate quantification of transcripts at single-cell resolution remains challenging for the much smaller microbial cells.
url https://journals.asm.org/doi/10.1128/mSphere.00411-21
work_keys_str_mv AT sergiodmorenovel225squez imagingandquantificationofmrnamoleculesatsinglecellresolutioninthehumanfungalpathogencandidaalbicans
AT jchristianp233rez imagingandquantificationofmrnamoleculesatsinglecellresolutioninthehumanfungalpathogencandidaalbicans
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