The effects of 1-methylnaphthalene after inhalation exposure on the serum corticosterone levels in rats
Objectives This paper reports on the trend of the stressogenic stimulus caused by a repeated exposure to 1-methylnaphthalene (1-MN) vapors at the nominal concentrations of 0 mg/m 3 (the control restrainer), 50 mg/m 3 or 200 mg/m 3 in the nose-only inhalation system, by analyzing the serum cortico...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nofer Institute of Occupational Medicine
2020-09-01
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| Series: | International Journal of Occupational Medicine and Environmental Health |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/ijomeh/EFFECTS-OF-1-METHYLNAPHTHALENE-AFTER-INHALATION-EXPOSURE-ON-BLOOD-CORTICOSTERONE,124085,0,2.html |
| Summary: | Objectives
This paper reports on the trend of the stressogenic stimulus caused by a repeated exposure to 1-methylnaphthalene (1-MN) vapors at
the nominal concentrations of 0 mg/m 3 (the control restrainer), 50 mg/m 3 or 200 mg/m 3 in the nose-only inhalation system, by analyzing the serum
corticosterone (CORT) levels in rats.
Material and Methods
Three groups of rats were exposed in restrainers to 1-MN vapors at the nominal concentrations
of 0 mg/m 3 , 50 mg/m 3 or 200 mg/m 3 for 5 days. One control group of animals spent all the time during the experiment in an individually
ventilated plastic cage. The serum CORT concentrations were determined in all 4 groups of the rats. The blood samples drawn from the tail vein
were collected every day after termination of the 6-h exposure. On the fifth day, blood samples were collected 15 min, 30 min, 45 min, 1 h, and 3 h
after termination of the 6-h exposure.
Results
On the fifth day of the study, no statistically significant changes in body weights between all groups of
animals were found. After 5 days of the observation, increased food intake in the control groups was noted. Significantly higher CORT concentrations
in the rats exposed to 1-MN at 200 mg/m 3 and in the animals from the control restrainer were found, comparing to the animals exposed to 1-MN at
50 mg/m 3 and the animals from the control cage.
Conclusions
The application of 6-h restraining induced high concentrations of the stress hormone,
CORT, in the blood of rats. The short-term exposure of rats to 1-MN non-linearly reduced the restraint stress measured with CORT concentration. Int J Occup Med Environ Health. 2020;33(5):691–9 |
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| ISSN: | 1232-1087 1896-494X |