Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells

Abstract Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR) cancer. In the present study, a clinically used...

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Bibliographic Details
Main Authors: Ying-Tzu Chang, Yu-Ning Teng, Kun-I Lin, Charles C. N. Wang, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Chin-Chuan Hung
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-48169-2