LEF1 silencing sensitizes colorectal cancer cells to oxaliplatin, 5-FU, and irinotecan

LEF1 silencing sensitizes colorectal cancer cells to oxaliplatin, 5-FU, and irinotecan

Colorectal cancer (CRC) is the third most prevalent cancer all around the world. Chemotherapy plays an essential role in the treatment of CRC while Oxaliplatin, Irinotecan, and 5 – fluorouracil (5-FU) are the most commonly used chemotherapeutic drugs. However, chemo-resistance is a major obstacle to...

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Bibliographic Details
Main Authors: Elham Fakhr, Fatemeh Zare, Kayhan Azadmanesh, Ladan Teimoori-Toolabi
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Colorectal Neoplasm
Chemo resistance
Wnt signaling
LEF1
Oxaliplatin
Irinotecan
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222100874X

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