Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.

Unilateral spatial neglect (USN) is one of the most common symptoms of right hemisphere damage; its classical symptom is that patients fail to respond to information on their left side. It has been postulated that disturbance of 2 separate attentional networks relates to the occurrence of USN. Howev...

Full description

Bibliographic Details
Main Authors: Tsutomu Sasaki, Masayuki Abe, Eiichi Okumura, Toyoji Okada, Kimito Kondo, Kensuke Sekihara, Wataru Ide, Hajime Kamada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023873/?tool=EBI
id doaj-aad8390be6df408380d61452dc8eadc5
record_format Article
spelling doaj-aad8390be6df408380d61452dc8eadc52021-03-03T20:20:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7341610.1371/journal.pone.0073416Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.Tsutomu SasakiMasayuki AbeEiichi OkumuraToyoji OkadaKimito KondoKensuke SekiharaWataru IdeHajime KamadaUnilateral spatial neglect (USN) is one of the most common symptoms of right hemisphere damage; its classical symptom is that patients fail to respond to information on their left side. It has been postulated that disturbance of 2 separate attentional networks relates to the occurrence of USN. However, little is known about the underlying mechanism and neuronal substrates. In this study, we measured spontaneous neural activity by means of magnetoencephalography in 13 patients with brain damage and 5 control subjects. To study the relationship between functional connectivity at rest and severity of USN symptoms, we determined the imaginary coherence values relating to the inter-hemispherical ventral and dorsal attentional networks, as well as the clinical severity of USN using neuropsychological tests and behavioral rating scales. The present results showed that inter-hemispherical connectivity in the ventral attentional network, especially between the left and right angular gyri, detected in the alpha band is associated with the severity of USN symptoms. This may suggest that connectivity of inter-hemispherical homologous regions of the ventral attentional network in the alpha band could be one of the biomarkers of attentional network imbalance occurring in patients with USN.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023873/?tool=EBI
collection DOAJ
language English
format Article
sources DOAJ
author Tsutomu Sasaki
Masayuki Abe
Eiichi Okumura
Toyoji Okada
Kimito Kondo
Kensuke Sekihara
Wataru Ide
Hajime Kamada
spellingShingle Tsutomu Sasaki
Masayuki Abe
Eiichi Okumura
Toyoji Okada
Kimito Kondo
Kensuke Sekihara
Wataru Ide
Hajime Kamada
Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.
PLoS ONE
author_facet Tsutomu Sasaki
Masayuki Abe
Eiichi Okumura
Toyoji Okada
Kimito Kondo
Kensuke Sekihara
Wataru Ide
Hajime Kamada
author_sort Tsutomu Sasaki
title Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.
title_short Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.
title_full Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.
title_fullStr Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.
title_full_unstemmed Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.
title_sort disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description Unilateral spatial neglect (USN) is one of the most common symptoms of right hemisphere damage; its classical symptom is that patients fail to respond to information on their left side. It has been postulated that disturbance of 2 separate attentional networks relates to the occurrence of USN. However, little is known about the underlying mechanism and neuronal substrates. In this study, we measured spontaneous neural activity by means of magnetoencephalography in 13 patients with brain damage and 5 control subjects. To study the relationship between functional connectivity at rest and severity of USN symptoms, we determined the imaginary coherence values relating to the inter-hemispherical ventral and dorsal attentional networks, as well as the clinical severity of USN using neuropsychological tests and behavioral rating scales. The present results showed that inter-hemispherical connectivity in the ventral attentional network, especially between the left and right angular gyri, detected in the alpha band is associated with the severity of USN symptoms. This may suggest that connectivity of inter-hemispherical homologous regions of the ventral attentional network in the alpha band could be one of the biomarkers of attentional network imbalance occurring in patients with USN.
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023873/?tool=EBI
work_keys_str_mv AT tsutomusasaki disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
AT masayukiabe disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
AT eiichiokumura disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
AT toyojiokada disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
AT kimitokondo disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
AT kensukesekihara disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
AT wataruide disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
AT hajimekamada disturbedrestingfunctionalinterhemisphericalconnectivityoftheventralattentionalnetworkinalphabandisassociatedwithunilateralspatialneglect
_version_ 1714822897946591232