The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet

The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet

Background: This study tested the hypothesis that Entresto could safely and effectively preserve heart and kidney function in rats with cardiorenal syndrome (CRS) induced by 5/6 nephrectomy and intra-peritoneal doxorubicin administration (accumulated dosage up to 7.5 mg/kg) together with daily high-...

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Bibliographic Details
Main Authors: Chih-Chao Yang, Yen-Ta Chen, Chih-Hung Chen, Yi-Chen Li, Pei-Lin Shao, Then-Hung Huang, Yi-Ling Chen, Cheuk-Kwan Sun, Hon-Kan Yip
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cardiorenal syndrome
Oxidative stress
Apoptosis
Mitochondrial damage
Entresto
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219305931

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