A smartphone-based test and predictive models for rapid, non-invasive, and point-of-care monitoring of ocular and cardiovascular complications related to diabetes

• Main Author: Kasyap Chakravadhanula
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Informatics in Medicine Unlocked
• Subjects: Diabetic retinopathy screening; Smartphone ophthalmology; Cardiovascular risk; Point-of-care screening; Machine learning; Computer vision
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352914820306365

Diabetes is a massive global problem, with growth especially rapid in developing regions, which can lead to several damaging complications. Among the most impactful of these are diabetic retinopathy, the leading cause of blindness among working class adults, and cardiovascular disease, the leading cause of death worldwide. However, diagnosis is often too late to prevent irreversible damage caused by these linked conditions. This study describes the development of an integrated test, automated and not requiring laboratory blood analysis, for screening of these conditions. First, a random forest model was developed by retrospectively analyzing the influence of various risk factors (obtained quickly and non-invasively) on cardiovascular risk. Next, a deep-learning model was developed for prediction of diabetic retinopathy from retinal fundus images by a modified and re-trained InceptionV3 image classification model. The input was simplified by automatically segmenting the blood vessels in the retinal image. The technique of transfer learning enables the model to capitalize on existing infrastructure on the target device, meaning more versatile deployment, especially helpful in low-resource settings. The models were integrated into a smartphone-based test, combined with an inexpensive 3D-printed retinal imaging attachment. Accuracy scores, as well as the receiver operating characteristic curve, the learning curve, and other gauges, were promising. This test is much cheaper and faster, enabling continuous monitoring for two damaging complications of diabetes. It has the potential to replace the manual methods of diagnosing both diabetic retinopathy and cardiovascular risk, which are time consuming and costly processes only done by medical professionals away from the point of care, and to prevent irreversible blindness and heart-related complications through faster, cheaper, and safer monitoring of diabetic complications. As well, tracking of cardiovascular and ocular complications of diabetes can enable improved detection of other diabetic complications, leading to earlier and more efficient treatment on a global scale.