Intracytoplasmic sperm injection in male renal transplant recipients

• Main Authors: Murat Berkkanoglu, Hasan Bulut, Kevin Coetzee, Kemal Ozgur
• Format: Article
• Language: English
• Published: SpringerOpen 2015-06-01
• Series: Middle East Fertility Society Journal
• Subjects: Renal transplant; Renal disease; Immunosuppression; Semen analysis; ICSI
• Online Access: http://www.sciencedirect.com/science/article/pii/S1110569014200082

Objective: In this study, we reviewed the reproductive outcomes following ICSI in 5 couples where the male partners had undergone renal transplantations. Chronic renal failure and dialysis may adversely affect male reproductive function resulting in severely depressed semen parameters or even azoospermia, which maybe further adversely affected by the immunosuppression taken from after transplantation. Study design: Case report. Setting: A private fertility clinic. Patients: The study included five infertile couples where the male partners were the recipients of renal transplants, 3–15 years prior to having ICSI treatment. All couples suffered from male factor infertility, with diagnoses of; azoospermia, asthenoteratozoospermia, oligoasthenoteratozoopsermia. Results: In the 5 case reports 5 ICSI and 3 FET treatment procedures were completed. In all but one of the cases grade 1 quality embryos were obtained and transferred. From the 8 embryo transfers performed 4 pregnancies were obtained, one miscarried at 8 weeks and 3 resulted in live births. Conclusions: In this study, we showed that pregnancy and normal live birth were possible following ICSI treatment for male factor infertility, where male partners had had renal transplants and were under immunosuppressive therapy.