Targeting of intracellular Ca2+ stores as a therapeutic strategy against age-related neurotoxicities
Abstract Calcium dysregulation often underlies pathologies associated with aging and age-associated neurodegenerative diseases. Cells express a unique pattern of Ca2+ channels and pumps geared to fulfill specific physiological requirements and there is a decline in the fidelity of these processes wi...
Main Authors: | Joshua Goldberg, Antonio Currais, Gamze Ates, Ling Huang, Maxim Shokhirev, Pamela Maher, David Schubert |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-08-01
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Series: | npj Aging and Mechanisms of Disease |
Online Access: | https://doi.org/10.1038/s41514-020-00048-1 |
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