Targeting of intracellular Ca2+ stores as a therapeutic strategy against age-related neurotoxicities

Abstract Calcium dysregulation often underlies pathologies associated with aging and age-associated neurodegenerative diseases. Cells express a unique pattern of Ca2+ channels and pumps geared to fulfill specific physiological requirements and there is a decline in the fidelity of these processes wi...

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Bibliographic Details
Main Authors: Joshua Goldberg, Antonio Currais, Gamze Ates, Ling Huang, Maxim Shokhirev, Pamela Maher, David Schubert
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-020-00048-1