PCSK9 Gene E670G Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis of 5,484 Subjects

• Main Authors: Yan-yan Li, Hui Wang, Xin-xing Yang, Hong-yu Geng, Ge Gong, Xin-zheng Lu
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-11-01
• Series: Frontiers in Cardiovascular Medicine
• Subjects: pcsk9; polymorphism; coronary artery disease; genetic; E670G
• Online Access: https://www.frontiersin.org/articles/10.3389/fcvm.2020.582865/full

Objective: Research has shown a possible relationship between the E670G polymorphism of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and an increased risk of coronary artery disease (CAD). However, there is no clear consensus on the subject because of conflicting results in the literature. The current meta-analysis was performed to better elucidate the potential relationship between the PCSK9 gene E670G polymorphism and CAD.Methods: There were 5,484 subjects from 13 individual studies who were included in the current meta-analysis. The fixed- or random-effects models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).Results: The current meta-analysis found a significant association between PCSK9 gene E670G polymorphism and CAD under allelic (OR = 1.79, 95% CI = 1.42–2.27, P = 1.00 × 10−6), dominant (OR = 2.16, 95% CI = 1.61–2.89, P = 2.22 × 10−7), heterozygous (OR = 2.02, 95% CI = 1.55–2.64, P = 2.47 × 10−7), and additive genetic models (OR = 1.92, 95% CI = 1.49–2.49, P = 6.70 × 10−7).Conclusions:PCSK9 gene E670G polymorphism was associated with an elevated risk of CAD, especially in the Chinese population. More specifically, carriers of the G allele carriers of the PCSK9 gene may be predisposed to developing CAD.