Multiparameter RNA and codon optimization: a standardized tool to assess and enhance autologous mammalian gene expression.

Multiparameter RNA and codon optimization: a standardized tool to assess and enhance autologous mammalian gene expression.

Autologous expression of recombinant human proteins in human cells for biomedical research and product development is often hampered by low expression yields limiting subsequent structural and functional analyses. Following RNA and codon optimization, 50 candidate genes representing five classes of...

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Bibliographic Details
Main Authors: Stephan Fath, Asli Petra Bauer, Michael Liss, Anne Spriestersbach, Barbara Maertens, Peter Hahn, Christine Ludwig, Frank Schäfer, Marcus Graf, Ralf Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3048298?pdf=render

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