Structural basis of host protein hijacking in human T-cell leukemia virus integration

Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting i...

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Main Authors:	Veer Bhatt, Ke Shi, Daniel J. Salamango, Nicholas H. Moeller, Krishan K. Pandey, Sibes Bera, Thomas E. Bohl, Fredy Kurniawan, Kayo Orellana, Wei Zhang, Duane P. Grandgenett, Reuben S. Harris, Anna C. Sundborger-Lunna, Hideki Aihara
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16963-6

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spelling	doaj-aa9b53faafb14e34a356550f154c5e2f2021-06-20T11:15:08ZengNature Publishing GroupNature Communications2041-17232020-06-011111910.1038/s41467-020-16963-6Structural basis of host protein hijacking in human T-cell leukemia virus integrationVeer Bhatt0Ke Shi1Daniel J. Salamango2Nicholas H. Moeller3Krishan K. Pandey4Sibes Bera5Thomas E. Bohl6Fredy Kurniawan7Kayo Orellana8Wei Zhang9Duane P. Grandgenett10Reuben S. Harris11Anna C. Sundborger-Lunna12Hideki Aihara13The Hormel Institute, University of MinnesotaMasonic Cancer Center, University of MinnesotaMasonic Cancer Center, University of MinnesotaMasonic Cancer Center, University of MinnesotaDepartment of Molecular Microbiology and Immunology, Saint Louis UniversityDepartment of Molecular Microbiology and Immunology, Saint Louis UniversityMasonic Cancer Center, University of MinnesotaMasonic Cancer Center, University of MinnesotaMasonic Cancer Center, University of MinnesotaMasonic Cancer Center, University of MinnesotaDepartment of Molecular Microbiology and Immunology, Saint Louis UniversityMasonic Cancer Center, University of MinnesotaThe Hormel Institute, University of MinnesotaMasonic Cancer Center, University of MinnesotaIntegration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting integration as part of the HTLV-1 intasome.https://doi.org/10.1038/s41467-020-16963-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Veer Bhatt Ke Shi Daniel J. Salamango Nicholas H. Moeller Krishan K. Pandey Sibes Bera Thomas E. Bohl Fredy Kurniawan Kayo Orellana Wei Zhang Duane P. Grandgenett Reuben S. Harris Anna C. Sundborger-Lunna Hideki Aihara
spellingShingle	Veer Bhatt Ke Shi Daniel J. Salamango Nicholas H. Moeller Krishan K. Pandey Sibes Bera Thomas E. Bohl Fredy Kurniawan Kayo Orellana Wei Zhang Duane P. Grandgenett Reuben S. Harris Anna C. Sundborger-Lunna Hideki Aihara Structural basis of host protein hijacking in human T-cell leukemia virus integration Nature Communications
author_facet	Veer Bhatt Ke Shi Daniel J. Salamango Nicholas H. Moeller Krishan K. Pandey Sibes Bera Thomas E. Bohl Fredy Kurniawan Kayo Orellana Wei Zhang Duane P. Grandgenett Reuben S. Harris Anna C. Sundborger-Lunna Hideki Aihara
author_sort	Veer Bhatt
title	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_short	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_full	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_fullStr	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_full_unstemmed	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_sort	structural basis of host protein hijacking in human t-cell leukemia virus integration
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting integration as part of the HTLV-1 intasome.
url	https://doi.org/10.1038/s41467-020-16963-6
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Structural basis of host protein hijacking in human T-cell leukemia virus integration

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