Inhibition of EZH2 Attenuates Sorafenib Resistance by Targeting NOTCH1 Activation-Dependent Liver Cancer Stem Cells via NOTCH1-Related MicroRNAs in Hepatocellular Carcinoma

Inhibition of EZH2 Attenuates Sorafenib Resistance by Targeting NOTCH1 Activation-Dependent Liver Cancer Stem Cells via NOTCH1-Related MicroRNAs in Hepatocellular Carcinoma

Acquired resistance and intrinsic to sorafenib therapy represents a major hurdle in improving the management of advanced hepatocellular carcinoma (HCC), which has been recently shown to be associated with the emergence of liver cancer stem cells (CSCs). However, it remains largely unknown whether an...

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Bibliographic Details
Main Authors: Shanshan Wang, Long Cai, Fengwei Zhang, Xuechai Shang, Rong Xiao, Hongjuan Zhou
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S193652331930587X

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