NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expre...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05910-1 |
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doaj-aa724b3e4c7b4ada9b67a708841b11952021-05-11T10:21:41ZengNature Publishing GroupNature Communications2041-17232018-08-019111410.1038/s41467-018-05910-1NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy modelJennifer M. Peterson0David J. Wang1Vikram Shettigar2Steve R. Roof3Benjamin D. Canan4Nadine Bakkar5Jonathan Shintaku6Jin-Mo Gu7Sean C. Little8Nivedita M. Ratnam9Priya Londhe10Leina Lu11Christopher E. Gaw12Jennifer M. Petrosino13Sandya Liyanarachchi14Huating Wang15Paul M. L. Janssen16Jonathan P. Davis17Mark T. Ziolo18Sudarshana M. Sharma19Denis C. Guttridge20Department of Cancer Biology and GeneticsDepartment of Cancer Biology and GeneticsCenter for Muscle Health and Neuromuscular DisordersCenter for Muscle Health and Neuromuscular DisordersCenter for Muscle Health and Neuromuscular DisordersDepartment of Cancer Biology and GeneticsDepartment of Cancer Biology and GeneticsDepartment of Cancer Biology and GeneticsCenter for Muscle Health and Neuromuscular DisordersDepartment of Cancer Biology and GeneticsDepartment of Cancer Biology and GeneticsLi Ka Shing Institute of Health Sciences, The Chinese University of Hong KongThe Ohio State University Medical CenterCenter for Muscle Health and Neuromuscular DisordersDepartment of Cancer Biology and GeneticsLi Ka Shing Institute of Health Sciences, The Chinese University of Hong KongCenter for Muscle Health and Neuromuscular DisordersCenter for Muscle Health and Neuromuscular DisordersCenter for Muscle Health and Neuromuscular DisordersDepartment of Biochemistry and Molecular Biology, Medical University of South CarolinaDepartment of Cancer Biology and GeneticsThe molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression.https://doi.org/10.1038/s41467-018-05910-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jennifer M. Peterson David J. Wang Vikram Shettigar Steve R. Roof Benjamin D. Canan Nadine Bakkar Jonathan Shintaku Jin-Mo Gu Sean C. Little Nivedita M. Ratnam Priya Londhe Leina Lu Christopher E. Gaw Jennifer M. Petrosino Sandya Liyanarachchi Huating Wang Paul M. L. Janssen Jonathan P. Davis Mark T. Ziolo Sudarshana M. Sharma Denis C. Guttridge |
| spellingShingle |
Jennifer M. Peterson David J. Wang Vikram Shettigar Steve R. Roof Benjamin D. Canan Nadine Bakkar Jonathan Shintaku Jin-Mo Gu Sean C. Little Nivedita M. Ratnam Priya Londhe Leina Lu Christopher E. Gaw Jennifer M. Petrosino Sandya Liyanarachchi Huating Wang Paul M. L. Janssen Jonathan P. Davis Mark T. Ziolo Sudarshana M. Sharma Denis C. Guttridge NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model Nature Communications |
| author_facet |
Jennifer M. Peterson David J. Wang Vikram Shettigar Steve R. Roof Benjamin D. Canan Nadine Bakkar Jonathan Shintaku Jin-Mo Gu Sean C. Little Nivedita M. Ratnam Priya Londhe Leina Lu Christopher E. Gaw Jennifer M. Petrosino Sandya Liyanarachchi Huating Wang Paul M. L. Janssen Jonathan P. Davis Mark T. Ziolo Sudarshana M. Sharma Denis C. Guttridge |
| author_sort |
Jennifer M. Peterson |
| title |
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model |
| title_short |
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model |
| title_full |
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model |
| title_fullStr |
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model |
| title_full_unstemmed |
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model |
| title_sort |
nf-κb inhibition rescues cardiac function by remodeling calcium genes in a duchenne muscular dystrophy model |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression. |
| url |
https://doi.org/10.1038/s41467-018-05910-1 |
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