NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expre...
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Bibliographic Details
| Main Authors: |
Jennifer M. Peterson,
David J. Wang,
Vikram Shettigar,
Steve R. Roof,
Benjamin D. Canan,
Nadine Bakkar,
Jonathan Shintaku,
Jin-Mo Gu,
Sean C. Little,
Nivedita M. Ratnam,
Priya Londhe,
Leina Lu,
Christopher E. Gaw,
Jennifer M. Petrosino,
Sandya Liyanarachchi,
Huating Wang,
Paul M. L. Janssen,
Jonathan P. Davis,
Mark T. Ziolo,
Sudarshana M. Sharma,
Denis C. Guttridge |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-05910-1
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