Can We Build Artificial Stem Cell Compartments?
Animals carry stem cells throughout their entire life, from embryogenesis to senescence. Their function during development and adulthood consists basically of forming and sustaining functional tissues while maintaining a small self-renewing population. They reside in a complex three-dimensional envi...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2003-01-01
|
| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/S1110724303208019 |
| id |
doaj-aa7241fb1d054b98accbd7adc6bf18c5 |
|---|---|
| record_format |
Article |
| spelling |
doaj-aa7241fb1d054b98accbd7adc6bf18c52020-11-25T01:27:27ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512003-01-012003316416910.1155/S1110724303208019Can We Build Artificial Stem Cell Compartments?Carlos E. Semino0Center for Biological Engineering and Biotechnology Process Engineering Center, Building 56-354, Massachusetts Institute of Technology, Cambridge 02139, MA, USAAnimals carry stem cells throughout their entire life, from embryogenesis to senescence. Their function during development and adulthood consists basically of forming and sustaining functional tissues while maintaining a small self-renewing population. They reside in a complex three-dimensional environment consisting of other nearby cells extracellular matrix components, endogenous or exogenous soluble factors, and physical, structural, or mechanical properties of the tissues they inhabit. Can we artificially recreate tissue development such that stem cells can both self-renew and be instructed to mature properly? The main factors required to regulate the maintenance and differentiation of some types of stem cells are known. In addition, new bioengineered synthetic materials that mimic extracellular matrix components can be used as initial scaffolding for building stem cell microenvironments.http://dx.doi.org/10.1155/S1110724303208019 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Carlos E. Semino |
| spellingShingle |
Carlos E. Semino Can We Build Artificial Stem Cell Compartments? Journal of Biomedicine and Biotechnology |
| author_facet |
Carlos E. Semino |
| author_sort |
Carlos E. Semino |
| title |
Can We Build Artificial Stem Cell Compartments? |
| title_short |
Can We Build Artificial Stem Cell Compartments? |
| title_full |
Can We Build Artificial Stem Cell Compartments? |
| title_fullStr |
Can We Build Artificial Stem Cell Compartments? |
| title_full_unstemmed |
Can We Build Artificial Stem Cell Compartments? |
| title_sort |
can we build artificial stem cell compartments? |
| publisher |
Hindawi Limited |
| series |
Journal of Biomedicine and Biotechnology |
| issn |
1110-7243 1110-7251 |
| publishDate |
2003-01-01 |
| description |
Animals carry stem cells throughout their entire life, from
embryogenesis to senescence. Their function during development
and adulthood consists basically of forming and sustaining
functional tissues while maintaining a small self-renewing
population. They reside in a complex three-dimensional environment
consisting of other nearby cells extracellular matrix components,
endogenous or exogenous soluble factors, and physical,
structural, or mechanical properties of the tissues they inhabit.
Can we artificially recreate tissue development such that stem
cells can both self-renew and be instructed to mature properly?
The main factors required to regulate the maintenance and
differentiation of some types of stem cells are known. In
addition, new bioengineered synthetic materials that mimic
extracellular matrix components can be used as initial
scaffolding for building stem cell microenvironments. |
| url |
http://dx.doi.org/10.1155/S1110724303208019 |
| work_keys_str_mv |
AT carlosesemino canwebuildartificialstemcellcompartments |
| _version_ |
1725105506530361344 |