A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

Abstract Background Interleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune encephalomyelitis (EAE). IL-6 is produced by multiple peripheral and centra...

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Bibliographic Details
Main Authors: Paula Sanchis, Olaya Fernández-Gayol, Gemma Comes, Kevin Aguilar, Anna Escrig, Mercedes Giralt, Richard D. Palmiter, Juan Hidalgo
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
DIO technology
Conditional reversible IL-6 knockout
Experimental autoimmune encephalomyelitis
Microglial IL-6
Online Access:http://link.springer.com/article/10.1186/s12974-020-01969-0

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