Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage

Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage

One of the challenges of synthetic self-assembled capsules is achieving selective recognition of specific cargoes. Here, authors synthesize a self-assembled porphyrin cubic cage that is capable of sequestering imidazole and thiazole-containing small molecules and peptides, protecting them from prote...

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Main Authors: Jesús Mosquera, Bartosz Szyszko, Sarah K. Y. Ho, Jonathan R. Nitschke
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14882
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spelling doaj-aa6b5f198c7d4869a569764651de33d12021-05-11T07:51:44ZengNature Publishing GroupNature Communications2041-17232017-03-01811610.1038/ncomms14882Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cageJesús Mosquera0Bartosz Szyszko1Sarah K. Y. Ho2Jonathan R. Nitschke3Department of Chemistry, University of CambridgeDepartment of Chemistry, University of CambridgeDepartment of Chemistry, University of CambridgeDepartment of Chemistry, University of CambridgeOne of the challenges of synthetic self-assembled capsules is achieving selective recognition of specific cargoes. Here, authors synthesize a self-assembled porphyrin cubic cage that is capable of sequestering imidazole and thiazole-containing small molecules and peptides, protecting them from proteolysis.https://doi.org/10.1038/ncomms14882
collection DOAJ
language English
format Article
sources DOAJ
author Jesús Mosquera
Bartosz Szyszko
Sarah K. Y. Ho
Jonathan R. Nitschke
spellingShingle Jesús Mosquera
Bartosz Szyszko
Sarah K. Y. Ho
Jonathan R. Nitschke
Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage
Nature Communications
author_facet Jesús Mosquera
Bartosz Szyszko
Sarah K. Y. Ho
Jonathan R. Nitschke
author_sort Jesús Mosquera
title Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage
title_short Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage
title_full Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage
title_fullStr Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage
title_full_unstemmed Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage
title_sort sequence-selective encapsulation and protection of long peptides by a self-assembled feii8l6 cubic cage
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-03-01
description One of the challenges of synthetic self-assembled capsules is achieving selective recognition of specific cargoes. Here, authors synthesize a self-assembled porphyrin cubic cage that is capable of sequestering imidazole and thiazole-containing small molecules and peptides, protecting them from proteolysis.
url https://doi.org/10.1038/ncomms14882
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AT sarahkyho sequenceselectiveencapsulationandprotectionoflongpeptidesbyaselfassembledfeii8l6cubiccage
AT jonathanrnitschke sequenceselectiveencapsulationandprotectionoflongpeptidesbyaselfassembledfeii8l6cubiccage
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