Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

Wimolsiri Iamsumang, Kanchana Leerunyakul, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat Suchonwanit Email poonkiat@hotmail.comAbstract: The currently approved treatment f...

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Main Authors: Iamsumang W, Leerunyakul K, Suchonwanit P
Format: Article
Language:English
Published: Dove Medical Press 2020-03-01
Series:Drug Design, Development and Therapy
Subjects:
Online Access:https://www.dovepress.com/finasteride-and-its-potential-for-the-treatment-of-female-pattern-hair-peer-reviewed-article-DDDT
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spelling doaj-aa6b4e2ec9ac4edb8bb12027579f18f12020-11-25T02:35:13ZengDove Medical PressDrug Design, Development and Therapy1177-88812020-03-01Volume 1495195952200Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to DateIamsumang WLeerunyakul KSuchonwanit PWimolsiri Iamsumang, Kanchana Leerunyakul, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat Suchonwanit Email poonkiat@hotmail.comAbstract: The currently approved treatment for female pattern hair loss (FPHL) includes topical minoxidil administration; however, this treatment fails to achieve hair regrowth in some patients. Finasteride, a selective 5α-reductase inhibitor (5-ARI), may be considered as an alternative treatment. However, because of its potential teratogenic effects, clinical studies and use of finasteride for FPHL are limited. In this review, we aim to summarize the literature regarding the pharmacology, clinical efficacy, and adverse effects of oral finasteride for the treatment of FPHL and to provide novel therapeutic options including topical finasteride and dutasteride, a new generation 5-ARI, for the treatment of FPHL.Keywords: alopecia, androgenetic alopecia, dutasteride, hair loss, topical finasteride, therapyhttps://www.dovepress.com/finasteride-and-its-potential-for-the-treatment-of-female-pattern-hair-peer-reviewed-article-DDDTalopeciaandrogenetic alopeciadutasteridehair losstopical finasteridetherapy
collection DOAJ
language English
format Article
sources DOAJ
author Iamsumang W
Leerunyakul K
Suchonwanit P
spellingShingle Iamsumang W
Leerunyakul K
Suchonwanit P
Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
Drug Design, Development and Therapy
alopecia
androgenetic alopecia
dutasteride
hair loss
topical finasteride
therapy
author_facet Iamsumang W
Leerunyakul K
Suchonwanit P
author_sort Iamsumang W
title Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_short Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_full Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_fullStr Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_full_unstemmed Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
title_sort finasteride and its potential for the treatment of female pattern hair loss: evidence to date
publisher Dove Medical Press
series Drug Design, Development and Therapy
issn 1177-8881
publishDate 2020-03-01
description Wimolsiri Iamsumang, Kanchana Leerunyakul, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat Suchonwanit Email poonkiat@hotmail.comAbstract: The currently approved treatment for female pattern hair loss (FPHL) includes topical minoxidil administration; however, this treatment fails to achieve hair regrowth in some patients. Finasteride, a selective 5α-reductase inhibitor (5-ARI), may be considered as an alternative treatment. However, because of its potential teratogenic effects, clinical studies and use of finasteride for FPHL are limited. In this review, we aim to summarize the literature regarding the pharmacology, clinical efficacy, and adverse effects of oral finasteride for the treatment of FPHL and to provide novel therapeutic options including topical finasteride and dutasteride, a new generation 5-ARI, for the treatment of FPHL.Keywords: alopecia, androgenetic alopecia, dutasteride, hair loss, topical finasteride, therapy
topic alopecia
androgenetic alopecia
dutasteride
hair loss
topical finasteride
therapy
url https://www.dovepress.com/finasteride-and-its-potential-for-the-treatment-of-female-pattern-hair-peer-reviewed-article-DDDT
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