Correlation of serum miR-202 expression with tumor marker levels and oncogene expression in patients with liver cancer

• Main Authors: Zhen Lu, Yu-Fen Wang, Ai-Xia Tian
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-07-01
• Series: Journal of Hainan Medical University
• Subjects: Liver cancer; miR-202; Tumor marker; Proliferation; Invasion
• Online Access: http://www.hnykdxxb.com/PDF/201807/16.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the correlation of serum miR-202 expression with tumor marker levels and oncogene expression in patients with liver cancer. Methods: A total of 58 patients with liver cancer who received surgical resection in Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science between July 2014 and October 2016 were selected as the liver cancer group of the research, and 42 healthy volunteers who received physical examination during the same period were selected as the control group of the research. Peripheral blood was collected to determine the expression of miR-202 and the levels of tumor markers; liver cancer tissue and adjacent tissue were collected to determine the mRNA expression of proliferation genes and invasion genes. Results: Serum miR-202 expression in liver cancer group was significantly lower than that in control group; serum GP73, GPC3, AFP and AFP-L3 levels in liver cancer group were significantly higher than those in control group and negatively correlated with serum miR-202 expression; LETM1, PI3K, AKT, FOXQ1, cyclinD1, c-myc, IFITM3, MMP9, Snail, N-cadherin and Vimentin mRNA expression in liver cancer tissue were significantly higher than those in adjacent tissue and negatively correlated with serum miR-202 expression. Conclusion: The lower serum miR-202 expression in patients with liver cancer is closely related to the abnormal proliferation and invasion of cancer cells.