Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development

Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development

Zygotic genome activation (ZGA), the onset of transcription after initial quiescence, is a major developmental step in many species. Here authors use single molecule tracking in live developing zebrafish embryos to show that increased transcription factor binding to DNA at ZGA is due to a shrinking...

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Main Authors: Matthias Reisser, Anja Palmer, Achim P. Popp, Christopher Jahn, Gilbert Weidinger, J. Christof M. Gebhardt
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07731-8
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spelling doaj-aa3a72768df54453a0f079cb56f836f52021-05-11T10:05:14ZengNature Publishing GroupNature Communications2041-17232018-12-019111110.1038/s41467-018-07731-8Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish developmentMatthias Reisser0Anja Palmer1Achim P. Popp2Christopher Jahn3Gilbert Weidinger4J. Christof M. Gebhardt5Institute of Biophysics, Ulm UniversityInstitute of Biophysics, Ulm UniversityInstitute of Biophysics, Ulm UniversityInstitute of Biochemistry and Molecular Biology, Ulm UniversityInstitute of Biochemistry and Molecular Biology, Ulm UniversityInstitute of Biophysics, Ulm UniversityZygotic genome activation (ZGA), the onset of transcription after initial quiescence, is a major developmental step in many species. Here authors use single molecule tracking in live developing zebrafish embryos to show that increased transcription factor binding to DNA at ZGA is due to a shrinking nucleus.https://doi.org/10.1038/s41467-018-07731-8
collection DOAJ
language English
format Article
sources DOAJ
author Matthias Reisser
Anja Palmer
Achim P. Popp
Christopher Jahn
Gilbert Weidinger
J. Christof M. Gebhardt
spellingShingle Matthias Reisser
Anja Palmer
Achim P. Popp
Christopher Jahn
Gilbert Weidinger
J. Christof M. Gebhardt
Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
Nature Communications
author_facet Matthias Reisser
Anja Palmer
Achim P. Popp
Christopher Jahn
Gilbert Weidinger
J. Christof M. Gebhardt
author_sort Matthias Reisser
title Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_short Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_full Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_fullStr Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_full_unstemmed Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_sort single-molecule imaging correlates decreasing nuclear volume with increasing tf-chromatin associations during zebrafish development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-12-01
description Zygotic genome activation (ZGA), the onset of transcription after initial quiescence, is a major developmental step in many species. Here authors use single molecule tracking in live developing zebrafish embryos to show that increased transcription factor binding to DNA at ZGA is due to a shrinking nucleus.
url https://doi.org/10.1038/s41467-018-07731-8
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AT anjapalmer singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment
AT achimppopp singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment
AT christopherjahn singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment
AT gilbertweidinger singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment
AT jchristofmgebhardt singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment
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