Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis

Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis

Abstract Escape from programmed cell death is a hallmark of cancer. In this study, we investigated the anti-apoptotic mechanisms and explored the therapeutic potential of BCL-2 homology domain-3 (BH3) mimetics in malignant pleural mesothelioma (MPM), a lethal thoracic malignancy with an extreme dear...

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Bibliographic Details
Main Authors: Duo Xu, Shun-Qing Liang, Zhang Yang, Haitang Yang, Rémy Bruggmann, Simone Oberhaensli, Sabina Berezowska, Thomas M. Marti, Sean R. R. Hall, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03668-x

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