Stem Cell Transplantation for Primary Immunodeficiency Disease: Experience of a Singapore Hospital

• Main Authors: Alison Joanne Lee, MBBS, MRCPCH, MMed, Jethro Wu, MBBS, Mariflor Sarmiento Villegas, MD, Lynette Pei-Chi Shek, MBBS, MRCP, Bee-Wah Lee, MBBS, MMed, MD, FRCP, FRCPCh, FAAAAI, Poh-Lin Tan, MBBS, MMed
• Format: Article
• Language: English
• Published: Elsevier 2012-01-01
• Series: World Allergy Organization Journal
• Online Access: http://www.sciencedirect.com/science/article/pii/S1939455119303813

We retrospectively analyzed the outcomes of hematopoietic stem cell transplantation in 7 patients with primary immunodeficiency diseases treated at the National University Hospital, Singapore, over the period from December 1996 to January 2010. The primary immunodeficiency diseases managed were X-linked hyperimmunoglobulin M syndrome (n = 3), severe combined immunodeficiency (n = 1), leukocyte adhesion deficiency type 1 (n = 1), chronic granulomatous disease (n = 1), and Wiskott-Aldrich syndrome (n = 1). The age of the patients ranged from 5 months to 17 years. Conditioning regimen depended on the type of immunodeficiency, whereas supportive treatment was tailored for differing pretransplant conditions. Eight stem cell transplantations were performed for 7 patients. Donors were HLA-matched sibling donors for 2 patients and unrelated donors for the rest. At the median follow-up of 8.6 years (range 2.2-15.0 years) as of December 2011, 6 patients were alive and cured of their primary diseases. Keywords: primary immunodeficiency, hematopoietic stem cell transplantation