Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions

Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions

Phagocytes, like neutrophils and macrophages, are specialized cells evolved to clear infectious pathogens. This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue and then to the killing of the invading pathog...

Full description

Bibliographic Details
Main Authors: Carlotta Costa, Giulia Germena, Emilio Hirsch
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2010.178
id doaj-aa206a2538554c859a3c1b6b18af5dfe
record_format Article
spelling doaj-aa206a2538554c859a3c1b6b18af5dfe2020-11-24T21:26:06ZengHindawi LimitedThe Scientific World Journal1537-744X2010-01-01101826183910.1100/tsw.2010.178Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic FunctionsCarlotta Costa0Giulia Germena1Emilio Hirsch2Department of Genetics, Biology, and Biochemistry, Molecular Biotechnology Center, University of Turin, ItalyDepartment of Genetics, Biology, and Biochemistry, Molecular Biotechnology Center, University of Turin, ItalyDepartment of Genetics, Biology, and Biochemistry, Molecular Biotechnology Center, University of Turin, ItalyPhagocytes, like neutrophils and macrophages, are specialized cells evolved to clear infectious pathogens. This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue and then to the killing of the invading pathogens. Molecular mechanisms underlying these processes are starting to emerge and point to the interplay between two families of crucial proteins: the PI3K lipid kinases and the Rac GTPases. This review focuses on how these two protein families contribute to migration, phagocytosis, and reactive oxygen species production, as well as their epistatic and feedback relations that finely tune these crucial aspects of the immune response.http://dx.doi.org/10.1100/tsw.2010.178
collection DOAJ
language English
format Article
sources DOAJ
author Carlotta Costa
Giulia Germena
Emilio Hirsch
spellingShingle Carlotta Costa
Giulia Germena
Emilio Hirsch
Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
The Scientific World Journal
author_facet Carlotta Costa
Giulia Germena
Emilio Hirsch
author_sort Carlotta Costa
title Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
title_short Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
title_full Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
title_fullStr Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
title_full_unstemmed Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
title_sort dissection of the interplay between class i pi3ks and rac signaling in phagocytic functions
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2010-01-01
description Phagocytes, like neutrophils and macrophages, are specialized cells evolved to clear infectious pathogens. This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue and then to the killing of the invading pathogens. Molecular mechanisms underlying these processes are starting to emerge and point to the interplay between two families of crucial proteins: the PI3K lipid kinases and the Rac GTPases. This review focuses on how these two protein families contribute to migration, phagocytosis, and reactive oxygen species production, as well as their epistatic and feedback relations that finely tune these crucial aspects of the immune response.
url http://dx.doi.org/10.1100/tsw.2010.178
work_keys_str_mv AT carlottacosta dissectionoftheinterplaybetweenclassipi3ksandracsignalinginphagocyticfunctions
AT giuliagermena dissectionoftheinterplaybetweenclassipi3ksandracsignalinginphagocyticfunctions
AT emiliohirsch dissectionoftheinterplaybetweenclassipi3ksandracsignalinginphagocyticfunctions
_version_ 1725980976698359808

Similar Items