Severe chronic osteomyelitis caused by Morganella morganii with high population diversity

Severe chronic osteomyelitis caused by Morganella morganii with high population diversity

A case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population struc...

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Main Authors: Jialiang Zhu, Haifeng Li, Li Feng, Min Yang, Ronggong Yang, Lin Yang, Li Li, Ruoyan Li, Minshan Liu, Shuxun Hou, Yuehua Ke, Wenfeng Li, Fan Bai
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:International Journal of Infectious Diseases
Subjects:
Chronic osteomyelitis
Morganella
Genetic diversity
Whole-genome sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971216311249
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spelling doaj-aa186c5d0c584c42bd5ba9f15f2c91d82020-11-24T23:52:33ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112016-09-0150C444710.1016/j.ijid.2016.07.016Severe chronic osteomyelitis caused by Morganella morganii with high population diversityJialiang Zhu0Haifeng Li1Li Feng2Min Yang3Ronggong Yang4Lin Yang5Li Li6Ruoyan Li7Minshan Liu8Shuxun Hou9Yuehua Ke10Wenfeng Li11Fan Bai12Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, ChinaDepartment of Medical Affairs, General Hospital of Beijing Military Region of PLA, Beijing, ChinaDepartment of Surgery Room, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, ChinaConstruction Engineering Research Institute, Xi’an, Shaanxi Province, ChinaDepartment of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, ChinaDepartment of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, ChinaDepartment of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, ChinaBiodynamic Optical Imaging Center, School of Life Science, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, ChinaBiodynamic Optical Imaging Center, School of Life Science, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, ChinaDepartment of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, ChinaInstitute of Disease Control and Prevention, AMMS, No. 20, Dongdajie, Fengtai District, Beijing 100071, ChinaDepartment of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, ChinaBiodynamic Optical Imaging Center, School of Life Science, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, ChinaA case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen, M. morganii, with high diversity, which might evolve during replication within the host.http://www.sciencedirect.com/science/article/pii/S1201971216311249Chronic osteomyelitisMorganellaGenetic diversityWhole-genome sequencing
collection DOAJ
language English
format Article
sources DOAJ
author Jialiang Zhu
Haifeng Li
Li Feng
Min Yang
Ronggong Yang
Lin Yang
Li Li
Ruoyan Li
Minshan Liu
Shuxun Hou
Yuehua Ke
Wenfeng Li
Fan Bai
spellingShingle Jialiang Zhu
Haifeng Li
Li Feng
Min Yang
Ronggong Yang
Lin Yang
Li Li
Ruoyan Li
Minshan Liu
Shuxun Hou
Yuehua Ke
Wenfeng Li
Fan Bai
Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
International Journal of Infectious Diseases
Chronic osteomyelitis
Morganella
Genetic diversity
Whole-genome sequencing
author_facet Jialiang Zhu
Haifeng Li
Li Feng
Min Yang
Ronggong Yang
Lin Yang
Li Li
Ruoyan Li
Minshan Liu
Shuxun Hou
Yuehua Ke
Wenfeng Li
Fan Bai
author_sort Jialiang Zhu
title Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
title_short Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
title_full Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
title_fullStr Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
title_full_unstemmed Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
title_sort severe chronic osteomyelitis caused by morganella morganii with high population diversity
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
1878-3511
publishDate 2016-09-01
description A case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen, M. morganii, with high diversity, which might evolve during replication within the host.
topic Chronic osteomyelitis
Morganella
Genetic diversity
Whole-genome sequencing
url http://www.sciencedirect.com/science/article/pii/S1201971216311249
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