Dietary thiols accelerate aging of C. elegans

Dietary thiols accelerate aging of C. elegans

Reactive oxygen species are required for the long lifespan, and glutathione is an antioxidant. Here the authors show that limiting the consumption of dietary thiols, including those naturally derived from the microbiota, increases proteotoxic stress resistance in worms and human cells, and extends C...

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Main Authors: Ivan Gusarov, Ilya Shamovsky, Bibhusita Pani, Laurent Gautier, Svetlana Eremina, Olga Katkova-Zhukotskaya, Alexander Mironov, Alexander А. Makarov, Evgeny Nudler
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24634-3
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spelling doaj-aa0cfd08560d47b397240eb7928949962021-07-18T11:42:08ZengNature Publishing GroupNature Communications2041-17232021-07-0112111410.1038/s41467-021-24634-3Dietary thiols accelerate aging of C. elegansIvan Gusarov0Ilya Shamovsky1Bibhusita Pani2Laurent Gautier3Svetlana Eremina4Olga Katkova-Zhukotskaya5Alexander Mironov6Alexander А. Makarov7Evgeny Nudler8Department of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineEngelhardt Institute of Molecular Biology, Russian Academy of ScienceEngelhardt Institute of Molecular Biology, Russian Academy of ScienceEngelhardt Institute of Molecular Biology, Russian Academy of ScienceEngelhardt Institute of Molecular Biology, Russian Academy of ScienceDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineReactive oxygen species are required for the long lifespan, and glutathione is an antioxidant. Here the authors show that limiting the consumption of dietary thiols, including those naturally derived from the microbiota, increases proteotoxic stress resistance in worms and human cells, and extends C. elegans lifespan.https://doi.org/10.1038/s41467-021-24634-3
collection DOAJ
language English
format Article
sources DOAJ
author Ivan Gusarov
Ilya Shamovsky
Bibhusita Pani
Laurent Gautier
Svetlana Eremina
Olga Katkova-Zhukotskaya
Alexander Mironov
Alexander А. Makarov
Evgeny Nudler
spellingShingle Ivan Gusarov
Ilya Shamovsky
Bibhusita Pani
Laurent Gautier
Svetlana Eremina
Olga Katkova-Zhukotskaya
Alexander Mironov
Alexander А. Makarov
Evgeny Nudler
Dietary thiols accelerate aging of C. elegans
Nature Communications
author_facet Ivan Gusarov
Ilya Shamovsky
Bibhusita Pani
Laurent Gautier
Svetlana Eremina
Olga Katkova-Zhukotskaya
Alexander Mironov
Alexander А. Makarov
Evgeny Nudler
author_sort Ivan Gusarov
title Dietary thiols accelerate aging of C. elegans
title_short Dietary thiols accelerate aging of C. elegans
title_full Dietary thiols accelerate aging of C. elegans
title_fullStr Dietary thiols accelerate aging of C. elegans
title_full_unstemmed Dietary thiols accelerate aging of C. elegans
title_sort dietary thiols accelerate aging of c. elegans
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description Reactive oxygen species are required for the long lifespan, and glutathione is an antioxidant. Here the authors show that limiting the consumption of dietary thiols, including those naturally derived from the microbiota, increases proteotoxic stress resistance in worms and human cells, and extends C. elegans lifespan.
url https://doi.org/10.1038/s41467-021-24634-3
work_keys_str_mv AT ivangusarov dietarythiolsaccelerateagingofcelegans
AT ilyashamovsky dietarythiolsaccelerateagingofcelegans
AT bibhusitapani dietarythiolsaccelerateagingofcelegans
AT laurentgautier dietarythiolsaccelerateagingofcelegans
AT svetlanaeremina dietarythiolsaccelerateagingofcelegans
AT olgakatkovazhukotskaya dietarythiolsaccelerateagingofcelegans
AT alexandermironov dietarythiolsaccelerateagingofcelegans
AT alexanderamakarov dietarythiolsaccelerateagingofcelegans
AT evgenynudler dietarythiolsaccelerateagingofcelegans
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