A Day in the Life of the Exon Junction Complex

The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cytoplasm and communicate the information about the...

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Main Authors:	Lena P. Schlautmann, Niels H. Gehring
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	Biomolecules
Subjects:	mRNA gene regulation RNA processing RNA-binding protein
Online Access:	https://www.mdpi.com/2218-273X/10/6/866

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spelling	doaj-aa019f5a36b4458ab676e9958ad649692020-11-25T03:08:38ZengMDPI AGBiomolecules2218-273X2020-06-011086686610.3390/biom10060866A Day in the Life of the Exon Junction ComplexLena P. Schlautmann0Niels H. Gehring1Institute for Genetics, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, GermanyInstitute for Genetics, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, GermanyThe exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cytoplasm and communicate the information about the splicing process and the position of introns. Specifically, the EJC’s core components and its associated proteins regulate different steps of gene expression, including pre-mRNA splicing, mRNA export, translation, and nonsense-mediated mRNA decay (NMD). This review summarizes the most important functions and main protagonists in the life of the EJC. It also provides an overview of the latest findings on the assembly, composition and molecular activities of the EJC and presents them in the chronological order, in which they play a role in the EJC’s life cycle.https://www.mdpi.com/2218-273X/10/6/866mRNAgene regulationRNA processingRNA-binding protein
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lena P. Schlautmann Niels H. Gehring
spellingShingle	Lena P. Schlautmann Niels H. Gehring A Day in the Life of the Exon Junction Complex Biomolecules mRNA gene regulation RNA processing RNA-binding protein
author_facet	Lena P. Schlautmann Niels H. Gehring
author_sort	Lena P. Schlautmann
title	A Day in the Life of the Exon Junction Complex
title_short	A Day in the Life of the Exon Junction Complex
title_full	A Day in the Life of the Exon Junction Complex
title_fullStr	A Day in the Life of the Exon Junction Complex
title_full_unstemmed	A Day in the Life of the Exon Junction Complex
title_sort	day in the life of the exon junction complex
publisher	MDPI AG
series	Biomolecules
issn	2218-273X
publishDate	2020-06-01
description	The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cytoplasm and communicate the information about the splicing process and the position of introns. Specifically, the EJC’s core components and its associated proteins regulate different steps of gene expression, including pre-mRNA splicing, mRNA export, translation, and nonsense-mediated mRNA decay (NMD). This review summarizes the most important functions and main protagonists in the life of the EJC. It also provides an overview of the latest findings on the assembly, composition and molecular activities of the EJC and presents them in the chronological order, in which they play a role in the EJC’s life cycle.
topic	mRNA gene regulation RNA processing RNA-binding protein
url	https://www.mdpi.com/2218-273X/10/6/866
work_keys_str_mv	AT lenapschlautmann adayinthelifeoftheexonjunctioncomplex AT nielshgehring adayinthelifeoftheexonjunctioncomplex AT lenapschlautmann dayinthelifeoftheexonjunctioncomplex AT nielshgehring dayinthelifeoftheexonjunctioncomplex
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A Day in the Life of the Exon Junction Complex

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