Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis

Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis

A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomi...

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Main Authors: Barbara Bojko, Marcin Wąsowicz, Janusz Pawliszyn
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177913000294
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spelling doaj-a9f92a6ba15d45b78e4effec840ce2fb2021-04-02T01:37:37ZengElsevierJournal of Pharmaceutical Analysis2095-17792014-02-0141613Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysisBarbara Bojko0Marcin Wąsowicz1Janusz Pawliszyn2Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1; Corresponding authors.Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada M5G 2C4Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1; Corresponding authors.A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported. Keywords: Metabolomics, Heart surgery, Cardiopulmonary bypass, Tranexamic acid, Direct immersion solid phase microextraction, LC/MShttp://www.sciencedirect.com/science/article/pii/S2095177913000294
collection DOAJ
language English
format Article
sources DOAJ
author Barbara Bojko
Marcin Wąsowicz
Janusz Pawliszyn
spellingShingle Barbara Bojko
Marcin Wąsowicz
Janusz Pawliszyn
Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis
Journal of Pharmaceutical Analysis
author_facet Barbara Bojko
Marcin Wąsowicz
Janusz Pawliszyn
author_sort Barbara Bojko
title Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis
title_short Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis
title_full Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis
title_fullStr Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis
title_full_unstemmed Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPMEâLCâMS analysis
title_sort metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: di-spmeâlcâms analysis
publisher Elsevier
series Journal of Pharmaceutical Analysis
issn 2095-1779
publishDate 2014-02-01
description A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported. Keywords: Metabolomics, Heart surgery, Cardiopulmonary bypass, Tranexamic acid, Direct immersion solid phase microextraction, LC/MS
url http://www.sciencedirect.com/science/article/pii/S2095177913000294
work_keys_str_mv AT barbarabojko metabolicprofilingofplasmafromcardiacsurgicalpatientsconcurrentlyadministeredwithtranexamicaciddispmealcamsanalysis
AT marcinwasowicz metabolicprofilingofplasmafromcardiacsurgicalpatientsconcurrentlyadministeredwithtranexamicaciddispmealcamsanalysis
AT januszpawliszyn metabolicprofilingofplasmafromcardiacsurgicalpatientsconcurrentlyadministeredwithtranexamicaciddispmealcamsanalysis
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