Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity

Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity

3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h wereprepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic andantiviral activities. Among all the compounds evaluate...

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Bibliographic Details
Main Authors: Mladen Mintas, Erik De Clercq, Jan Balzarini, Krešimir Pavelic, Marijeta Kralj, Katja Ester, Silvana Raic-Malic, Branka Zorc, Zrinka Rajic
Format: Article
Language:English
Published: MDPI AG 2006-11-01
Series:Molecules
Subjects:
Hydantoin
L- and D-amino acids
antiviral activity
antitumoral activity.
Online Access:http://www.mdpi.com/1420-3049/11/11/837/

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