Anti-inflammatory effect of luteolin in acute gouty arthritis rat model

• Main Authors: Rui-Ming Shen, Liang-Bao Zhong, Guo-Quan Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-09-01
• Series: Journal of Hainan Medical University
• Subjects: luteolin; gout arthritis; inflammatory factors; interleukin17
• Online Access: http://www.hnykdxxb.com/PDF/201917/5.pdf

Objective: To explore the anti-inflammatory effect of luteolin on rats with acute gout arthritis. Methods: A total of forty-eight rats were chosen and randomly divided into six groups. The acute gout arthritis model of rats was established by injecting monosodium urate at the concentration of 25 mg/mL into the ankle joint cavity. Changes of joint swelling index at different time points and the levels of IL-1β, IL-17, TNF-α, IL-6 in serum and synovial were measured. Results: Compared with the control group, the swelling index of ankle joint and gait score in the model group was significantly enhanced at different time points (all P＜0.01). Compared with the MSU group, luteolin improved the ankle swelling index of rats with acute gout arthritis (P<0.05), and significantly down-regulated the levels of IL-1β, IL-17, TNF-α, IL-6 (P<0.01). Conclusion: Luteolin can alleviate the inflammatory response of acute gouty arthritis and may be an effective drug for acute gouty arthritis.