Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics

Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics

Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization ba...

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Bibliographic Details
Main Authors: Pankaj Singh, Prabodh Pandey, Shivam Shukla, Naren Naik, Asima Pradhan
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Applied Sciences
Subjects:
optical parameters
beveled fiber
spatially resolved reflectance
epithelial pre-cancer
look-up table
Online Access:https://www.mdpi.com/2076-3417/10/24/8836
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spelling doaj-a9e0280f852e46a6a7206d973f63d7bd2020-12-11T00:03:01ZengMDPI AGApplied Sciences2076-34172020-12-01108836883610.3390/app10248836Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer DiagnosticsPankaj Singh0Prabodh Pandey1Shivam Shukla2Naren Naik3Asima Pradhan4Department of Physics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaDepartment of Physics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaCenter for Lasers and Photonics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaCenter for Lasers and Photonics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaDepartment of Physics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaFiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data.https://www.mdpi.com/2076-3417/10/24/8836optical parametersbeveled fiberspatially resolved reflectanceepithelial pre-cancerlook-up table
collection DOAJ
language English
format Article
sources DOAJ
author Pankaj Singh
Prabodh Pandey
Shivam Shukla
Naren Naik
Asima Pradhan
spellingShingle Pankaj Singh
Prabodh Pandey
Shivam Shukla
Naren Naik
Asima Pradhan
Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
Applied Sciences
optical parameters
beveled fiber
spatially resolved reflectance
epithelial pre-cancer
look-up table
author_facet Pankaj Singh
Prabodh Pandey
Shivam Shukla
Naren Naik
Asima Pradhan
author_sort Pankaj Singh
title Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
title_short Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
title_full Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
title_fullStr Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
title_full_unstemmed Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
title_sort modelling, design and validation of spatially resolved reflectance based fiber optic probe for epithelial precancer diagnostics
publisher MDPI AG
series Applied Sciences
issn 2076-3417
publishDate 2020-12-01
description Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data.
topic optical parameters
beveled fiber
spatially resolved reflectance
epithelial pre-cancer
look-up table
url https://www.mdpi.com/2076-3417/10/24/8836
work_keys_str_mv AT pankajsingh modellingdesignandvalidationofspatiallyresolvedreflectancebasedfiberopticprobeforepithelialprecancerdiagnostics
AT prabodhpandey modellingdesignandvalidationofspatiallyresolvedreflectancebasedfiberopticprobeforepithelialprecancerdiagnostics
AT shivamshukla modellingdesignandvalidationofspatiallyresolvedreflectancebasedfiberopticprobeforepithelialprecancerdiagnostics
AT narennaik modellingdesignandvalidationofspatiallyresolvedreflectancebasedfiberopticprobeforepithelialprecancerdiagnostics
AT asimapradhan modellingdesignandvalidationofspatiallyresolvedreflectancebasedfiberopticprobeforepithelialprecancerdiagnostics
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