Molecular evidence of functional progesterone withdrawal in human myometrium
How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11565 |
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doaj-a9cbb860df8546a38946568c449db5602021-05-11T10:35:47ZengNature Publishing GroupNature Communications2041-17232016-05-01711910.1038/ncomms11565Molecular evidence of functional progesterone withdrawal in human myometriumLubna Nadeem0Oksana Shynlova1Elzbieta Matysiak-Zablocki2Sam Mesiano3Xuesen Dong4Stephen Lye5Lunenfeld Tanenbaum Research Institute, Mount Sinai HospitalLunenfeld Tanenbaum Research Institute, Mount Sinai HospitalLunenfeld Tanenbaum Research Institute, Mount Sinai HospitalDepartment of Reproductive Biology, Case Western Reserve UniversityDepartment of Obstetrics & Gynecology, University of TorontoLunenfeld Tanenbaum Research Institute, Mount Sinai HospitalHow human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A.https://doi.org/10.1038/ncomms11565 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lubna Nadeem Oksana Shynlova Elzbieta Matysiak-Zablocki Sam Mesiano Xuesen Dong Stephen Lye |
| spellingShingle |
Lubna Nadeem Oksana Shynlova Elzbieta Matysiak-Zablocki Sam Mesiano Xuesen Dong Stephen Lye Molecular evidence of functional progesterone withdrawal in human myometrium Nature Communications |
| author_facet |
Lubna Nadeem Oksana Shynlova Elzbieta Matysiak-Zablocki Sam Mesiano Xuesen Dong Stephen Lye |
| author_sort |
Lubna Nadeem |
| title |
Molecular evidence of functional progesterone withdrawal in human myometrium |
| title_short |
Molecular evidence of functional progesterone withdrawal in human myometrium |
| title_full |
Molecular evidence of functional progesterone withdrawal in human myometrium |
| title_fullStr |
Molecular evidence of functional progesterone withdrawal in human myometrium |
| title_full_unstemmed |
Molecular evidence of functional progesterone withdrawal in human myometrium |
| title_sort |
molecular evidence of functional progesterone withdrawal in human myometrium |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-05-01 |
| description |
How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A. |
| url |
https://doi.org/10.1038/ncomms11565 |
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1721447972008361984 |