Molecular evidence of functional progesterone withdrawal in human myometrium
How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11565 |
| Summary: | How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A. |
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| ISSN: | 2041-1723 |