The Effects of Medical Treatments on Bone Mineral Density and Laboratory Data in Osteoporosis Patients

• Main Authors: Ferda Özdemir, Özlem Tükenmez, Nesrin Turan, Siranuş Kokino
• Format: Article
• Language: English
• Published: Galenos Yayinevi 2003-03-01
• Series: Türk Osteoporoz Dergisi
• Subjects: Osteoporosis; bone mineral density; laboratory parameters
• Online Access: http://www.turkosteoporozdergisi.org/article_4079/The-Effects-Of-Medical-Treatments-On-Bone-Mineral-Density-And-Laboratorydata-In-Osteoporosis-Patients

This study was carried out in order to compare the effects and relations between the scores of bone mineral density (BMD) values and laboratory data parameters such as serum Ca, Mg, P, ALP, creatinine, urinary Ca, creatinine, creatinine clearance before and after different treatments in patients with senil and postmenopausal OP. 251 female patients referred to OP outpatient clinic, were included in this study. The baseline demographic characteristics were inquired. BMD measurments were performed with DEXA and laboratory data related to bone metabolism such as serum Ca, P, Mg, ALP, creatinine; urinary Ca, creatinine, creatinine clearance, were obtained before and after treatment periods. The patients were divided into 7 groups according to their different medical treatments (Ca, Ca+Vit D, Ca+active Vit D, Calcitonin+Ca), Alendronate 10-70 mg+Ca, Risedronate+Ca regarding similar treatment durations. The comparisons between laboratory data and BMD values were investigated. According to the results statistical correlations were found; 1. Between P and femoral neck BMD (r=0.525, p=0.030), urinary Ca and ward’s triangle BMD (r=0.525, p=0.044) in the first group; 2. Between ALP and L2 BMD (r=0.652, p=0.04), Ca and L3 BMD (r=0.672, p=0.033) in the second group; 3. Between ALP and L2 BMD (r=-0.360, p=0.000), (r=-0.360, p=0.000), ALP and L3 (r=-0.229, p=0.029), urinary Ca and femoral neck BMD (r=0.238, p=0.029) in fourth group; 4. Between Mg and throcanteric BMD (r=0.599, p=0.024) in the sixth group; 5. Between P and femoral neck BMD (r=0.377, p=0.014), urinary Ca and L3 BMD (r=0.319, p=0.040) in seventh group. Up to day, there is no consensus about the choice of medical treatment for OP. It is reported that researches made on the effectiveness of the OP treatments often were condratiction to each other. We conclude that different kinds of medical treatments used in OP were effective on increasing BMD values, however there was not any evident effect on laboratory data parameters.