Recurrent sleep fragmentation induces insulin and neuroprotective mechanisms in middle-aged flies

Recurrent sleep fragmentation induces insulin and neuroprotective mechanisms in middle-aged flies

Lack of quality sleep increases central nervous system oxidative stress and impairs removal of neurotoxic soluble metabolites from brain parenchyma. During aging poor sleep quality, caused by sleep fragmentation, increases central nervous system cellular stress. Currently, it is not known how organi...

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Bibliographic Details
Main Authors: Michael J Williams, Emelie Perland, Mikaela M. Eriksson, Josef Carlsson, Daniel Erlandsson, Loora Laan, Tabusi Mahebali, Ella Potter, Robert Fredriksson, Christian Benedict, Helgi B. Schiöth
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Dopamine
Glucagon
Insulin
Metabolism
Sleep
Nrf2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00180/full

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