Gender peculiarities of gastroesophageal reflux disease

• Main Authors: T. Y. Spasova, E. V. Grigorieva
• Format: Article
• Language: Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 2015-04-01
• Series: Acta Biomedica Scientifica
• Subjects: gastroesophageal reflux disease; nonerosive reflux disease; erosive esophagitis; gender differences; risk factors
• Online Access: https://www.actabiomedica.ru/jour/article/view/27

We studied gender-specific clinical manifestations and risk factors for gastroesophageal reflux disease (GERD) in the urban population of Ulan-Ude. The study included 352 patients with GERD. It was found that in both sexes prevailed not erosive reflux disease. It was detected in 64,2% of men and in 88% of women (p = 0,005). Men significantly more often had severe forms of the disease: erosive esophagitis - 19,8% more often than in women (p = 0,04), in 2,9% of men we revealed esophageal ulcers, in 1,1% - Barrett esophagus, while the in women didn't have these forms of the disease. Daily repeated heartburn was found in women twice more often than in men. Average grade of GERD-Q questionnaire for women was also significantly higher than for men by 19% (p = 0,04). Women had higher levels of anxiety and depression (average grade on BDI was higher by 29% than in men). Men had significantly more frequently such risk factors as smoking, alcohol intake and women more often had diabetes, hypertension and coronary heart disease.