Expression of tight junction and drug efflux transporter proteins in an in vitro model of human blood-brain barrier

Expression of tight junction and drug efflux transporter proteins in an in vitro model of human blood-brain barrier

Interendothelial cell tight junctions (TJs) proteins contribute to maintain the structural and functional integrity of the blood-brain barrier (BBB) and several efflux transporters regulate transport of compounds across BBB. A unique double compartment-model of the BBB, consisting of cerebral endoth...

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Bibliographic Details
Main Authors: Chiara eCioni, Elisa eTurlizzi, Ugo eZanelli, Giuseppe eOliveri, Pasquale eAnnunziata
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Psychiatry
Subjects:
Blood-Brain Barrier
Tight Junctions
cell culture
brain endothelium
glia
drug transporters
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00047/full

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