c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway[S]

c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway[S]

Oxidative stress, hepatic steatosis, and mitochondrial dysfunction are key pathophysiological features of nonalcoholic fatty liver disease. A conjugated linoleic acid (CLA) mixture of cis9,trans11 (9,11-CLA) and trans10,cis12 (10,12-CLA) isomers enhanced the antioxidant/detoxifying mechanism via the...

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Bibliographic Details
Main Authors: Maria Pina Mollica, Giovanna Trinchese, Gina Cavaliere, Chiara De Filippo, Ennio Cocca, Marcello Gaita, Antonio Della-Gatta, Angela Marano, Giuseppe Mazzarella, Paolo Bergamo
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Journal of Lipid Research
Subjects:
nuclear factor E2-related factor-2
fatty acids
mitochondrial efficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375039

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