Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring

Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring

Objective(s): The link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (GDM), but the underlying mechanisms for this phenomenon are still not clear. Reduced β-cells mass is a determ...

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Bibliographic Details
Main Authors:	Zahra Nazari, Mohammad Nabiuni, Mohsen Saeidi, Mohammad Jafar Golalipour
Format:	Article
Language:	English
Published:	Mashhad University of Medical Sciences 2017-02-01
Series:	Iranian Journal of Basic Medical Sciences
Subjects:	Gene expression Gestational diabetes mellitus Langerhans islets Offspring
Online Access:	http://ijbms.mums.ac.ir/article_8240_645605c2fe3d88504726c0f3f1e04631.pdf

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