Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

In humans, the divalent metal ion transporter-1 (DMT1) mediates the transport of ferrous iron across the apical membrane of enterocytes. Hence, its inhibition could be beneficial for the treatment of iron overload disorders. Here we characterize the interaction of aromatic bis-isothiourea-substitute...

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Bibliographic Details
Main Authors: Cristina Manatschal, Jonai Pujol-Giménez, Marion Poirier, Jean-Louis Reymond, Matthias A Hediger, Raimund Dutzler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
transition metal ion transport
hemochromatosis
competittive inhibition
X-ray crystallography
reconstitution
Online Access:https://elifesciences.org/articles/51913

Internet

https://elifesciences.org/articles/51913

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