Intra-frame Motion Compensation in Multi-frame Brain PET Imaging

Purpose: Inter-frame and intra-frame motion can adversely impact the performance of dynamic brain PET imaging. Only correcting the former can still result in degraded qualitative and quantitative performance. Meanwhile, patient motion introduces mismatches between transmission and emission data whi...

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Main Authors: Hassan Mohy-ud-Din, Nicolas A-Karakatsanis, William Willis, Abdel K-Tahari, Dean F-Wong, Arman Rahmim
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2015-06-01
Series:Frontiers in Biomedical Technologies
Subjects:
Online Access:https://fbt.tums.ac.ir/index.php/fbt/article/view/46
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spelling doaj-a98f8bbb03864fd3a020cda87bec86242020-11-25T03:59:38ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372015-06-0122Intra-frame Motion Compensation in Multi-frame Brain PET ImagingHassan Mohy-ud-Din0Nicolas A-Karakatsanis1William Willis2Abdel K-Tahari3Dean F-Wong4Arman Rahmim5Department of Electrical and Computer Engineering, Johns Hopkins University, MD, USA AND Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, MD, USA.Division of Nuclear Medicine, University of Geneva, Geneva, Switzerland.Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, MD, USA.Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, MD, USA.Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, MD, USA.Department of Electrical and Computer Engineering, Johns Hopkins University, MD, USA AND Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, MD, USA. Purpose: Inter-frame and intra-frame motion can adversely impact the performance of dynamic brain PET imaging. Only correcting the former can still result in degraded qualitative and quantitative performance. Meanwhile, patient motion introduces mismatches between transmission and emission data which may lead to incorrect attenuation and scatter compensation in the reconstruction process. As a result, the reconstructed dynamic images may carry erroneous estimates of radioactivity distribution. We seek a solution to this problem. Methods: We investigated the use of iterative deconvolution coupled with a proposed use of time-weighted averaging of motion-transformed transmission images to correct the transmission-emission mismatch artifacts in dynamic brain PET images. We performed simulations using real-patient motion profile acquired by the infrared Polaris Vicra motion tracking device which estimates 3-D motion transformations during PET acquisition. This was followed by frame-based motion correction employing three different transmission-emission alignment strategies: transmission image transformed by (1) mean motion transformation, (2) median motion transformation, and (3) the proposed time-weighted average of motion-transformed transmission images. Results-: The results demonstrate that the proposed approach of using time-weighted averaging of motion transformed transmission images outperforms conventional methods by substantially reducing the transmission-emission mismatch artifacts in the reconstructed images. Coupled with an alignment of the reconstructed frames for inter-frame motion correction and a subsequent iterative deconvolution approach for intra-frame motion correction, the resulting motion compensated images showed superior quality, considerable reduction in error norm and enhanced noise-bias performance compared to conventional methods of transmission-emission mismatch compensation. The performance was consistent across different levels of intra-frame motion, and the algorithm was amenable to different framing schemes. Conclusion: In frame-based motion correction of dynamic PET images, it is feasible to achieve intra-frame motion compensation using time-weighted averaging of motion transformed transmission images coupled with a post-reconstruction iterative deconvolution procedure to compensate for intra-frame motion. https://fbt.tums.ac.ir/index.php/fbt/article/view/46Dynamic PET imagingTransmission/ Emission mismatchartifactsartifactsInter-frame and Intra-frame motionMotion compensation
collection DOAJ
language English
format Article
sources DOAJ
author Hassan Mohy-ud-Din
Nicolas A-Karakatsanis
William Willis
Abdel K-Tahari
Dean F-Wong
Arman Rahmim
spellingShingle Hassan Mohy-ud-Din
Nicolas A-Karakatsanis
William Willis
Abdel K-Tahari
Dean F-Wong
Arman Rahmim
Intra-frame Motion Compensation in Multi-frame Brain PET Imaging
Frontiers in Biomedical Technologies
Dynamic PET imaging
Transmission/ Emission mismatchartifacts
artifacts
Inter-frame and Intra-frame motion
Motion compensation
author_facet Hassan Mohy-ud-Din
Nicolas A-Karakatsanis
William Willis
Abdel K-Tahari
Dean F-Wong
Arman Rahmim
author_sort Hassan Mohy-ud-Din
title Intra-frame Motion Compensation in Multi-frame Brain PET Imaging
title_short Intra-frame Motion Compensation in Multi-frame Brain PET Imaging
title_full Intra-frame Motion Compensation in Multi-frame Brain PET Imaging
title_fullStr Intra-frame Motion Compensation in Multi-frame Brain PET Imaging
title_full_unstemmed Intra-frame Motion Compensation in Multi-frame Brain PET Imaging
title_sort intra-frame motion compensation in multi-frame brain pet imaging
publisher Tehran University of Medical Sciences
series Frontiers in Biomedical Technologies
issn 2345-5837
publishDate 2015-06-01
description Purpose: Inter-frame and intra-frame motion can adversely impact the performance of dynamic brain PET imaging. Only correcting the former can still result in degraded qualitative and quantitative performance. Meanwhile, patient motion introduces mismatches between transmission and emission data which may lead to incorrect attenuation and scatter compensation in the reconstruction process. As a result, the reconstructed dynamic images may carry erroneous estimates of radioactivity distribution. We seek a solution to this problem. Methods: We investigated the use of iterative deconvolution coupled with a proposed use of time-weighted averaging of motion-transformed transmission images to correct the transmission-emission mismatch artifacts in dynamic brain PET images. We performed simulations using real-patient motion profile acquired by the infrared Polaris Vicra motion tracking device which estimates 3-D motion transformations during PET acquisition. This was followed by frame-based motion correction employing three different transmission-emission alignment strategies: transmission image transformed by (1) mean motion transformation, (2) median motion transformation, and (3) the proposed time-weighted average of motion-transformed transmission images. Results-: The results demonstrate that the proposed approach of using time-weighted averaging of motion transformed transmission images outperforms conventional methods by substantially reducing the transmission-emission mismatch artifacts in the reconstructed images. Coupled with an alignment of the reconstructed frames for inter-frame motion correction and a subsequent iterative deconvolution approach for intra-frame motion correction, the resulting motion compensated images showed superior quality, considerable reduction in error norm and enhanced noise-bias performance compared to conventional methods of transmission-emission mismatch compensation. The performance was consistent across different levels of intra-frame motion, and the algorithm was amenable to different framing schemes. Conclusion: In frame-based motion correction of dynamic PET images, it is feasible to achieve intra-frame motion compensation using time-weighted averaging of motion transformed transmission images coupled with a post-reconstruction iterative deconvolution procedure to compensate for intra-frame motion.
topic Dynamic PET imaging
Transmission/ Emission mismatchartifacts
artifacts
Inter-frame and Intra-frame motion
Motion compensation
url https://fbt.tums.ac.ir/index.php/fbt/article/view/46
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AT nicolasakarakatsanis intraframemotioncompensationinmultiframebrainpetimaging
AT williamwillis intraframemotioncompensationinmultiframebrainpetimaging
AT abdelktahari intraframemotioncompensationinmultiframebrainpetimaging
AT deanfwong intraframemotioncompensationinmultiframebrainpetimaging
AT armanrahmim intraframemotioncompensationinmultiframebrainpetimaging
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