Plant-derived isoquinoline alkaloids that target ergosterol biosynthesis discovered by using a novel antifungal screening tool

Plant-derived isoquinoline alkaloids that target ergosterol biosynthesis discovered by using a novel antifungal screening tool

The ergosterol pathway is a prime antifungal target as it is required for fungal survival, yet is not involved in human homeostasis. Methods to study the ergosterol pathway, however, are often time-consuming. The minimum inhibitory concentration (MIC) assay is a simple research tool that determines...

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Bibliographic Details
Main Authors:	Siu Wah Wong-Deyrup, Xun Song, Tsz-Wai Ng, Xiu-Bin Liu, Jian-Guo Zeng, Zhi-Xing Qing, Stephen T. Deyrup, Zhen-Dan He, Hong-Jie Zhang
Format:	Article
Language:	English
Published:	Elsevier 2021-05-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Fungi Ergosterol pathway Dermatophytes Chelerythrine Sanguinarine
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332221001335

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